Search Result

Search Results for " 3cl protease "

Targets

Compounds

Recombinant Proteins

Cat No.	Product Name	Synonyms	Targets
T60045	NK01-63	NK01 63	SARS-CoV
	NK01-63 (Coronastat) is a potent inhibitor of the SARS-CoV-2 3CL protease.		SARS-CoV
T9716	Ensitrelvir	S-217622	SARS-CoV
	Ensitrelvir (S-217622) is an orally active inhibitor of SARS-CoV-2 3CL protease with IC50 of 13 nM.		SARS-CoV
T9574	PF-07304814	Lufotrelvir
	Lufotrelvir (PF-07304814) is a phosphate prodrug of PF-00835231 which acts as a potent 3CL pro protease ( M pro ) inhibitor with SARS-CoV-2 antiviral activity. Lufotrelvir binds and inhibits SARS-CoV-2 3CL pro activity w...
T6738	Z-FA-FMK		SARS-CoV , Cysteine Protease
	Z-FA-FMK can irreversibly inhibit cysteine protease and also inhibit effector caspases.		SARS-CoV , Cysteine Protease
T69841	GC813 sodium
	GC813 is a potent and permeable inhibitor of MERS coronavirus 3CL protease. GC813 is analogue of GC376.
T40340	SARS-CoV-2-IN-10
	SARS-CoV-2-IN-10 is a powerful and non-toxic inhibitor of SARS-CoV-2 3CL protease, with IC50 and EC50 values of 0.13 nM and 1.03 nM, respectively. The SARS-CoV-2 3C-like protease (3CLpro) is a critical enzyme for viral r...
T63385	SARS-CoV-2 3CLpro-IN-2
	SARS-CoV-2 3CLpro-IN-2 is a potent inhibitor of the 3CL protease pair and has shown research potential for SARS-CoV-2 disease.
T79867	Ibuzatrelvir	PF-07817883	Virus Protease
	Ibuzatrelvir (PF-07817883) is an antiviral compound designed to inhibit the SARS-CoV-2 3CL protease, and is utilized in the treatment of COVID-19 [1].		Virus Protease
T72371	SARS-CoV-2 3CLpro-IN-7
	SARS-CoV-2 3CLpro-IN-7 is a reversible covalent inhibitor of the SARS-CoV-2 3CL protease, exhibiting an inhibitory concentration (IC50) value of 1.4 µM.
T82623	D1N52		SARS-CoV
	D1N52 is a potent inhibitor of the SARS-CoV-2 3CL protease, demonstrating an inhibitory concentration half-maximal (IC50) value of 0.53 μM [1].		SARS-CoV
T79660	SARS-CoV-2 3CLpro-IN-17		SARS-CoV
	Compound 3h, also known as SARS-CoV-2 3CLpro-IN-17, is a selective inhibitor of the SARS-CoV-2 3CL protease, demonstrating an IC50 of 0.322 μM [1].		SARS-CoV
T74807	SARS-CoV-2 3CLpro-IN-13
	SARS-CoV-2 3CLpro-IN-13 is a potent inhibitor of the SARS-CoV-2 3CL protease, demonstrating significant anti-coronavirus activity with an IC50 value of 21 nM [1].
T82622	D1N8		SARS-CoV
	D1N8 is a potent inhibitor of the SARS-CoV-2 3CL protease, displaying an IC50 value of 0.44 μM and a CC50 value of greater than 20 μM. It holds promise for the development of anti-SARS-CoV-2 agents that target the 3CL pr...		SARS-CoV
T61774	SARS 3CLpro-IN-1
	SARS 3CLpro-IN-1 (Compound 3b) is a stereo-specific SARS 3CL protease inhibitor that belongs to the octahydroisochromene scaffold. It demonstrates inhibition against the P1 site imidazole, with an IC50 value of 95 μM [1]...
T40358	Ensitrelvir fumarate	S-217622 fumarate
	Ensitrelvir (S-217622) fumarate is a novel orally active inhibitor, targeting the SARS-CoV-2 3CL protease (IC50 = 13 nM). It demonstrates non-covalent and non-peptidic characteristics. This compound represents a pioneeri...
T79866	Zevotrelvir		SARS-CoV
	Zevotrelvir (Compound 52) serves as an inhibitor of coronavirus, demonstrating IC50 values below 0.1 μM for 229E hCoV protease and below 0.1 mM for SARS-CoV-3C-like (3CL) protease, suggesting its potential for researchin...		SARS-CoV
T79218	SARS-CoV-2-IN-41		SARS-CoV
	SARS-CoV-2-IN-41 (compound 2) is a potent inhibitor of SARS-CoV-2 3CL protease, exhibiting an IC50 of 0.022 µM and demonstrating antiviral efficacy [1].		SARS-CoV
T73052	Pomotrelvir	PBI-0451
	Pomotrelvir (PBI-0451) is a selective, orally administered inhibitor of the SARS-CoV-2 3CL protease, exhibiting antiviral properties suitable for research into the novel coronavirus (COVID-19).
T80657	SARS-CoV-2 3CLpro-IN-15		Virus Protease
	SARS-CoV-2 3CLpro-IN-15 (compound a), a beta-nitrostyrene derivative, acts as an inhibitor of the SARS-CoV-2 3CL protease (3CLpro), effectively inhibiting viral replication and transcription. It is instrumental in the id...		Virus Protease
T72312	SARS-CoV-2 3CLpro-IN-10
	SARS-CoV-2 3CLpro-IN-10(5d) is a potent inhibitor of the SARS-CoV-2 3CL protease, exhibiting an IC50 value of 190 nM, and demonstrates varied efficiency against other coronaviruses with IC50 values of 790 nM for SARS-CoV...
T72370	SARS-CoV-2 3CLpro-IN-6
	SARS-CoV-2 3CLpro-IN-6 is a reversible covalent inhibitor targeting the SARS-CoV-2 3CL protease, demonstrating potent inhibitory activity with an IC50 of 4.9 μM. It is utilized in the research of coronavirus disease 2019...
T63537	SARS-CoV-2 3CLpro-IN-1
	SARS-CoV-2 3CLpro-IN-1 (Compound 14c) is a highly potent inhibitor specifically designed to target and inhibit the activity of SARS-CoV-2 3CL pro, which is a cysteine-protease found in the main coronaviruses. This partic...
T72313	SARS-CoV-2 3CLpro-IN-11
	SARS-CoV-2 3CLpro-IN-11(11d) is a broad-spectrum antiviral compound that effectively inhibits the SARS-CoV-2 3CL protease, achieving an IC50 of 140 nM. Additionally, it exhibits inhibitory activity against SARS-CoV-1 and...
T78119	Z-L(D-Val)G-CHN2		HSV
	Z-L(D-Val)G-CHN2, an isoform of Z-LVG-CHN2, serves as a cell-permeable and irreversible inhibitor of cysteine proteinase. This tripeptide derivative emulates a segment of the human cysteine proteinase-binding center and ...		HSV
T73898	Paritaprevir dihydrate
	Paritaprevir dihydrate (ABT-450), a highly effective and orally administered antiviral, acts as a non-structural protein 3/4A (NS3/4A) protease inhibitor, displaying EC50 values of 1 and 0.21 nM against HCV genotypes 1a ...

Compounds

Target: SARS-CoV, Cysteine Protease

SARS-CoV-2 3CLpro-IN-2

Target: Virus Protease

SARS-CoV-2 3CLpro-IN-7

SARS-CoV-2 3CLpro-IN-17

T79660

Synonym:

Target: SARS-CoV

SARS-CoV-2 3CLpro-IN-13

Synonym: S-217622 fumarate

SARS-CoV-2 3CLpro-IN-15

T80657

Synonym:

Target: Virus Protease

SARS-CoV-2 3CLpro-IN-10

T72312

Synonym:

Target:

SARS-CoV-2 3CLpro-IN-6

T72370

Synonym:

Target:

SARS-CoV-2 3CLpro-IN-1

T63537

Synonym:

Target:

SARS-CoV-2 3CLpro-IN-11

Paritaprevir dihydrate

T73898

Synonym:

Target:

Recombinant Proteins

Species：

Expression System：

Tag：

Cat No.	Product Name	Species	Expression System
TMPK-01342	3CLpro/3C-like Protease Protein (A191V), SARS-COV-2, Recombinant	SARS-CoV-2	E. coli
	3CL protease, a viral cysteine proteinase, plays an important role in co-translational proteolytic processing of Coronavirus polyproteins. The 3CL protease cleaves as much as 11 sites in the replicase polyproteins and al...
TMPK-01338	3CLpro/3C-like Protease Protein (H172Y), SARS-COV-2, Recombinant	SARS-CoV-2	E. coli
	3CL protease, a viral cysteine proteinase, plays an important role in co-translational proteolytic processing of Coronavirus polyproteins. The 3CL protease cleaves as much as 11 sites in the replicase polyproteins and al...
TMPK-01340	3CLpro/3C-like Protease Protein (F140A), SARS-COV-2, Recombinant	SARS-CoV-2	E. coli
	3CL protease, a viral cysteine proteinase, plays an important role in co-translational proteolytic processing of Coronavirus polyproteins. The 3CL protease cleaves as much as 11 sites in the replicase polyproteins and al...
TMPK-01341	3CLpro/3C-like Protease Protein (P132H), SARS-COV-2, Recombinant	SARS-CoV-2	E. coli
	3CL protease, a viral cysteine proteinase, plays an important role in co-translational proteolytic processing of Coronavirus polyproteins. The 3CL protease cleaves as much as 11 sites in the replicase polyproteins and al...
TMPK-01339	3CLpro/3C-like Protease Protein (S144A), SARS-COV-2, Recombinant	SARS-CoV-2	E. coli
	3CL protease, a viral cysteine proteinase, plays an important role in co-translational proteolytic processing of Coronavirus polyproteins. The 3CL protease cleaves as much as 11 sites in the replicase polyproteins and al...
TMPK-01343	3CLpro/3C-like Protease Protein (A191T), SARS-COV-2, Recombinant	SARS-CoV-2	E. coli
	3CL protease, a viral cysteine proteinase, plays an important role in co-translational proteolytic processing of Coronavirus polyproteins. The 3CL protease cleaves as much as 11 sites in the replicase polyproteins and al...
TMPK-01347	3CLpro/3C-like Protease Protein (E166A), SARS-COV-2, Recombinant	SARS-CoV-2	E. coli
	3CL protease, a viral cysteine proteinase, plays an important role in co-translational proteolytic processing of Coronavirus polyproteins. The 3CL protease cleaves as much as 11 sites in the replicase polyproteins and al...
TMPK-01337	3CLpro/3C-like Protease Protein (Q189K), SARS-COV-2, Recombinant	SARS-CoV-2	E. coli
	3CL protease, a viral cysteine proteinase, plays an important role in co-translational proteolytic processing of Coronavirus polyproteins. The 3CL protease cleaves as much as 11 sites in the replicase polyproteins and al...
TMPK-01336	3CLpro/3C-like Protease Protein (L50F, E166V), SARS-COV-2, Recombinant	SARS-CoV-2	E. coli
	3CL protease, a viral cysteine proteinase, plays an important role in co-translational proteolytic processing of Coronavirus polyproteins. The 3CL protease cleaves as much as 11 sites in the replicase polyproteins and al...
TMPK-01335	3CLpro/3C-like Protease Protein (E166V), SARS-COV-2, Recombinant	SARS-CoV-2	E. coli
	3CL protease, a viral cysteine proteinase, plays an important role in co-translational proteolytic processing of Coronavirus polyproteins. The 3CL protease cleaves as much as 11 sites in the replicase polyproteins and al...
TMPK-01344	3CLpro/3C-like Protease Protein (L167F), SARS-COV-2, Recombinant	SARS-CoV-2	E. coli
	3CL protease, a viral cysteine proteinase, plays an important role in co-translational proteolytic processing of Coronavirus polyproteins. The 3CL protease cleaves as much as 11 sites in the replicase polyproteins and al...
TMPK-01346	3CLpro/3C-like Protease Protein (L50F), SARS-COV-2, Recombinant	SARS-CoV-2	E. coli
	3CL protease, a viral cysteine proteinase, plays an important role in co-translational proteolytic processing of Coronavirus polyproteins. The 3CL protease cleaves as much as 11 sites in the replicase polyproteins and al...
TMPK-01345	3CLpro/3C-like Protease Protein (L50F, E166A, L167F), SARS-COV-2, Recombinant	SARS-CoV-2	E. coli
	3CL protease, a viral cysteine proteinase, plays an important role in co-translational proteolytic processing of Coronavirus polyproteins. The 3CL protease cleaves as much as 11 sites in the replicase polyproteins and al...
TMPK-01348	3CLpro/3C-like Protease Protein, SARS-COV-2, Recombinant (aa 1-306)	SARS-CoV-2	E. coli
	3CL protease, a viral cysteine proteinase, plays an important role in co-translational proteolytic processing of Coronavirus polyproteins. The 3CL protease cleaves as much as 11 sites in the replicase polyproteins and al...
TMPJ-01448	3CLpro/3C-like Protease Protein, SARS-CoV-2, Recombinant (His)	2019-nCoV	E. coli
	The viral main proteinase (M pro , also called 3CL pro ), which controls the activities of the coronavirus replication complex. It functions as a cysteine protease engaging in the proteolytic cleavage of the viral precur...
TMPJ-01449	3CLpro/3C-like Protease Protein, SARS-CoV-2, Recombinant	SARS-CoV-2	E. coli
	The viral main proteinase (M pro , also called 3CL pro ), which controls the activities of the coronavirus replication complex. It functions as a cysteine protease engaging in the proteolytic cleavage of the viral precur...